Hazards all reactants, products, and solvents must be handled in a. From paba, you will make benzocaine or a benzocaine analog. Pdf local anesthetic activity of paminobenzohydroxamic acid in. Oxidation of benzocaine sce as a reference electrode. The oxidation products of benzocaine the oxidation of benzocaine has been carried out with aps at were dissolved at a concentration of 2. Youll learn to compare and contrast both drugs based on their forms, uses, effectiveness in pain relief, and side effects. Pdf the analysis of the physicochemical properties of. Synthesis and evaluation of some new thiazoleoxazole derivatives for their biological activities article pdf available in world journal of pharmacy and pharmaceutical sciences 58.
And the reason why its called that is we started with the carboxylic acid. They are used in numerous types ofsynthetic reactions, to create different products for a vast array of purposes, including medicinaland cosmetic. To produce an ester, one can utilize an esterification reaction. And he won the nobel prize in 1902 generally for his work in organic chemistry. The synthesis of benzocaine, a common anesthetic prelab readingvideo.
The aim of the current investigation is to investigate the acidcatalysed fischer esterification mechanism underlying the synthesis of the anaesthetic benzocaine using paminobenzoic acid and ethanol in excess. Refer to the structure of procaine in the table in the above introduction, local anesthetics. Pdf microwaveassisted synthesis of local anaesthetic. Watch until the end for a chance to win some benzocaine i used 150ml etoh 15gm. The resulting synthesised compound was subject to ir and melting point analyses in. The classic, optimal way of benzocaine synthesis is the reduction of the nitro. Synthesising benzocaine via reflux with a condenser uk essays. Today im demonstrating the synthesis of benzocaine.
Benzocaine is the ethyl ester of 4aminobenzoic acid 2. As a counter electrode, large surface platinum plate was used. Synthesis of benzocainelocal anaesthetic with the yield. Benzocaine 8ispreparedfrompmethylacetanilide3part c in scheme 1 in a threestep reaction sequence, involving procedures described in this journal14 and in several laboratory instruction manuals overall yields of about 12 to 22 %. Start studying chem 2081 experiment 8 synthesis of benzocaine. The preparation of the local anesthetic, benzocaine chem. Local anesthetics are agents that block the sensory transmission from a. In this experiment, the synthesis of benzocaine 2 is carried out by the acidcatalyzed esterification of 4aminobenzoic 1 acid with ethanol. Remote work advice from the largest allremote company. Synthesis and characterisation of benzocaine experiment practical report.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. Pdf chemical oxidative polymerization of benzocaine. The polymorphs of benzocaine were obtained by means of techniques commonly used for the preparation of various pharmaceutical dosage forms. The preparation of the practicals was thoroughly explained in the organic chemistry laboratory manual year 2. This article describes one of the projects in the advanced undergraduate organic chemistry laboratory course concerning the synthesis of two local anesthetic drugs, prilocaine and benzocaine, with a common threestep sequence starting from toluene. Here we combine irvibrational spectroscopy with ion mobilitymass spectrometry imms to. Chem 2081 experiment 8 synthesis of benzocaine quizlet. The preparation of the local anesthetic, benzocaine, by an esterification reaction. Monoclinic form of ethyl 4aminobenzoate benzocaine article pdf available in acta crystallographica section e structure reports online 587 july 2002 with 126 reads how we measure reads.